Windows vCenter 5.5 – When you install the inventory service; you are prompted for a small/medium/large inventory size.
Here is a link to the table to compare the JVM maximum heap sizes.
For a Large size, support had me set the Web Client is set for 3GB due to web client loading issues (times out).
Issue – When you update vCenter Server 5.5 Update 3d to 3e; it changes the wrapper.java.maxmemory from 3072m to 2048m in file
The fix is to backup the file and edit line 63 so wrapper.java.maxmemory=3072m then restart the VirtualCenter Management Web services and Web Client service. It is not clear on the order.